Clinical trials and clinical research are essential for advancing medical knowledge, improving patient care, and developing new treatments and therapies for the patients who need them. Execution of this vital work requires collaboration, innovation, and strategic decision-making. Now in its 16th year of fostering these joint efforts to advance our medical knowledge inclusive of all stakeholders, SCOPE Summit 2025 will take place February 3rd-6th, 2025, in Orlando, FL at the Rosen Shingle Creek. Over four stimulating days of in-depth discussions and networking in 28 different conferences, a bustling exhibit hall with 200 companies, 3 plenary keynote sessions, the 8th annual Participant Engagement Awards, the inaugural Site Innovation Award, special cross-department panels, the 3rd annual Master of Clinical Research golf tournament, a Super Bowl Tailgate Party, and a boutique investor conference, the programming focuses on advances and innovative solutions in all aspects of clinical trial innovation, planning, management, operations, and investment. SCOPE welcomes more than 3,300 attendees, 850 different organizations, from 27 countries, in clinical operations, innovation, and research.