State-of-the-art and emerging topics pertaining to the field of Parallel and Distributed Computing paradigms and applications. The conference aims at presenting original and unpublished research that will target state-of-the-art as well as emerging topics pertaining to the field of Parallel and Distributed Computing paradigms and applications. Parallel and Distributed Computing is today a central topic in computer science, engineering and society in the development of new approaches for the modeling, design, analysis, evaluation, and programming of future parallel and distributed computing systems and applications. Thus, modern scientific applications need to be integrated into an entire Compute Continuum from the edge all the way to supercomputers and large data-centers using flexible infrastructures and middlewares. This year’s edition of ISPDC makes a highlight on the efficient support for processing across such a Computing Continuum.